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Preparation of a new chiral building block containing a benzylic quaternary stereogenic center and a formal total synthesis of (−)-physostigmine

Authors
Journal
Tetrahedron Asymmetry
0957-4166
Publisher
Elsevier
Publication Date
Volume
19
Issue
19
Identifiers
DOI: 10.1016/j.tetasy.2008.09.021

Abstract

Abstract This paper describes the preparation of a new chiral building block containing a benzylic quaternary stereogenic center via the highly enantioselective PLE-mediated hydrolysis of dimethyl 2-(2-chloro-5-methoxyphenyl)-2-methylmalonate, as well as the absolute configuration of the new chiral building block, which has been elucidated through the formal total synthesis of (−)-physostigmine.

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