To clarify the influence of contacts with journal which has different misalignment angles on engine bearing fatigue phenomenon, the experiments and the theoretical analyses were carried out. The bearing material are two types of aluminum-zinc-silicon alloys with overlay on the steel back metal. The occurrence of the fatigue in the misaligned contact portion qualitatively coincides with the maximum oil film pressure position and the amplitude of oil film pressure fluctuation is in accordance with the result from the elastohydrodynamic lubrication (EHL) analysis in which the uneven contact is taken into consideration. The fatigue cracks of the bearing alloy at the uneven contact portion occur first in the direction perpendicular to the sliding direction of the shaft. The comparison of the fatigue strength of two types of aluminum-zinc-silicon alloys revealed that the material with the greater tensile strength also had the greater fatigue strength. Furthermore, the elongation of the materials did not have a direct influence on fatigue strength.