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Carnitine-acylcarnitine translocase activity in cardiac mitochondria from aged rats: the effect of acetyl-L-carnitine

Authors
Journal
Mechanisms of Ageing and Development
0047-6374
Publisher
Elsevier
Publication Date
Volume
84
Issue
2
Identifiers
DOI: 10.1016/0047-6374(95)01636-8
Keywords
  • Aging
  • Fatty Acids Oxidation
  • Carnitine Translocase
  • Cardiolipin
  • Acetyl-L-Carnitine
  • Rat Heart Mitochondria

Abstract

Abstract Age-related changes in mitochondrial fatty acids metabolism may underlie the progressive decline in cardiac function. The effect of aging and acute treatment with acetyl-L-carnitine on fatty acids oxidation and on carnitine-acylcarnitine translocase activity in rat heart mitochondria was studied. Rates of palmitoylcarnitine supported respiration as well as carnitine-carnitine and carnitine-palmitoylcarnitine exchange reactions were all depressed (approx. 35%) in heart mitochondria from aged rats. These effects were almost completely reversed following treatment of aged rats with acetyl-L-carnitine. Heart mitochondrial cardiolipin content was significantly reduced (approx. 38%) in aged rats. Treatment of aged rats with acetyl-L-carnitine restored the level of cardiolipin to that of young rats. It is suggested that acetyl-L-carnitine is able to reverse age-related decrement in mitochondrial carnitine-acylcarnitine exchange activity by restoring the normal cardiolipin content.

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