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Role of glycosylation in bovine leukemia virus infection

Springer (Biomed Central Ltd.)
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DOI: 10.1186/1742-4690-8-s1-a29
  • Meeting Abstract
  • Biology
  • Medicine
  • Pharmacology


Role of glycosylation in bovine leukemia virus infection MEETING ABSTRACT Open Access Role of glycosylation in bovine leukemia virus infection Amel-Baya Bouzar, Alix de Brogniez*, Arnaud Florins, Carole François, Mathieu Boxus, Luc Willems From 15th International Conference on Human Retroviruses: HTLV and Related Viruses Leuven and Gembloux, Belgium. 5-8 June 2011 As a model for HTLV, reverse genetics can be used in the bovine leukemia virus (BLV) system to identify important mechanisms of viral persistence and patho- genesis. The question addressed here pertains to the role of glycans bound to the BLV envelope glycoprotein (SU gp51). Addition of carbohydrates to the BLV SU potentially creates a structure called « glycan shield » that confers resistance to the virus against the host immune response. On the other hand, glycosylation can also modulate attachment of the virus to the cell membrane. To unravel the role of SU glycosylation, three comple- mentary strategies were developed: pharmacological inhibition of different glycosylation pathways, interfer- ence with glycan attachment and site-directed mutagen- esis of N-glycosylation sites in an infectious BLV provirus. Collectively, our results demonstrate that gly- cosylation is important for the Gp51 maturation process, for virus infection in vitro and for infectivity in vivo. Published: 6 June 2011 doi:10.1186/1742-4690-8-S1-A29 Cite this article as: Bouzar et al.: Role of glycosylation in bovine leukemia virus infection. Retrovirology 2011 8(Suppl 1):A29. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at * Correspondence: [email protected] Cellular and Molecular Biol

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