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Distribution of the two forms of guinea-pig β2-microglobulin originally detected in urine

Authors
Journal
Molecular Immunology
0161-5890
Publisher
Elsevier
Publication Date
Volume
20
Issue
12
Identifiers
DOI: 10.1016/0161-5890(83)90170-0

Abstract

Abstract Two distinct forms of β 2-microglubin (β 2m) have been detected in pooled guinea-pig serum from outbred animals using ultrafiltration, gel filtration and ion exchange chromatography. These two forms probably correspond to the two β 2m forms, with different electrophoretic mobility, that have been previously identified in guinea-pig urine. In solubilized membranes from perfused guinea-pig livers only the basic form of β 2m could be found. These results may indicate that the two β 2m forms should not be ascribed to genetic polymorphism but rather are a result of post-translational modification.

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