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Synthesis and evaluation of a spiro-isobenzofuranone class of histamine H3receptor inverse agonists

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
18
Issue
18
Identifiers
DOI: 10.1016/j.bmcl.2008.07.125
Keywords
  • Histamine H3Inverse Agonist
  • Spiro-Isobenzofuranone
  • Pet Tracer
  • Brain Permeability
Disciplines
  • Pharmacology

Abstract

Abstract Spiro-isobenzofuranones 1a and 1b were discovered as potent, selective, and brain-penetrable non-imidazole H 3 receptor inverse agonists. Our corporate sample collection was screened to identify 2a as a lead. Recognizing the right-hand portion of 2a as an essential pharmacophore, an extensive screen of the left-hand piperidine portion was carried out to yield the potent spiro-derivatives 2t− x. Spiro-isobenzofuranone 2x, the most potent among the derivatives, was converted to the corresponding amide 1a, which possessed dramatically improved H 3 activity (IC 50 = 0.72 nM; more than 20-fold improvement over 2x). Further elaboration led to the identification of 1b, a 5-methoxy derivative with an IC 50 of 0.54 nM. Our studies demonstrated that derivatives 1a and 1b to be potent, selective, and brain-penetrable H 3 inverse agonists.

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