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Biosynthesis of androgens by the sesterterpene pathway via 23,24-dinor-4-cholen-3-one

Authors
Journal
The Journal of Steroid Biochemistry and Molecular Biology
0960-0760
Publisher
Elsevier
Publication Date
Volume
41
Identifiers
DOI: 10.1016/0960-0760(92)90440-t

Abstract

Abstract Rat testicular and adrenal gland microsomal preparations were incubated with 23,24-dinor-5-cholen-3β-ol (Guneribol) a proposed intermediate in the sesterterpene pathway for steroid biosynthesis. Steroids were isolated, purified by thin layer and high-performance liquid chromatography and crystallized to constant specific radioactivity. These preparations converted the substrate to 23,24-dinor-4-cholen-3-one. Radioactive 23,24-dinor-4-cholen-3-one was synthesized and incubated with further tissue preparations and shown to be converted to steroid hormones. These findings suggest that 23,24-dinor-4-cholen-3-one is an intermediate on the sesterterpene pathway for steroidogenesis.

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