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ANTIBODIES TO MEMBRANE ANTIGEN(S) COMMON TO THYMOCYTES AND A SUBPOPULATION OF LYMPHOCYTES IN INFECTIOUS-MONONUCLEOSIS SERA

Authors
Journal
The Lancet
0140-6736
Publisher
Elsevier
Publication Date
Volume
299
Issue
7747
Identifiers
DOI: 10.1016/s0140-6736(72)90854-9
Disciplines
  • Medicine

Abstract

Abstract IgM antibodies against surface membrane antigen(s), present on both human thymocytes and lymphocytes, have been identified in the sera of twelve out of forty-seven (25%) infectious-mononucleosis patients by indirect immunofluorescent staining of viable cells. Maximum staining was obtained at 3°C. There was an inverse relation between the number of immunoglobulin-bearing lymphocytes and those which stained with the IgM antibodies. It is suggested that such cold antibodies react with a fraction of thymus-derived (T) lymphocytes.

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