Abstract Background: Writing a scientific manuscript is an important component of academic medicine. For most novice writers, this task may seem quite formidable. Discussion: This article will review the basic processes of writing a manuscript, with emphasis on the proper structure and organization of the article. The likelihood of a manuscript being accepted is highly dependent on its content and structure. A structured outline is the cornerstone of a successful manuscript. Conclusion: The current article presents the tools necessary for writing a successful manuscript.