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A cyclin-like protein, ClgA, regulates development in Aspergillus nidulans

Authors
Journal
Research in Microbiology
0923-2508
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.resmic.2014.04.003
Keywords
  • Asexual Development
  • Sexual Development
  • Cyclin-Like Protein
  • Temperature Sensitive
Disciplines
  • Biology

Abstract

Abstract A cyclin-like protein from Aspergillus nidulans, ClgA, was identified. Its cyclin-like subunit shares 28.3% identity to Saccharomyces cerevisiae Clg1. Deletion of clgA slightly influenced fungal growth, but repressed asexual development and made it more sensitive to temperature variations. It also downregulated expression of brlA, abaA and wetA, which are critically responsible for asexual development. Sexual development was impaired in the ΔclgA mutant. Its related genes, veA and nosA, were expressed weakly in the ΔclgA mutant, while nsdD expression showed the opposite behavior. Generally, ClgA functioned differently from other reported cyclins in development of A. nidulans.

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