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Erythrodermic mycosis fungoides with hypereosinophilic syndrome: a rare presentation

Authors
Journal
ecancermedicalscience
1754-6605
Publisher
Cancer Intelligence
Publication Date
Identifiers
DOI: 10.3332/ecancer.2013.337
Keywords
  • Case Report
Disciplines
  • Biology
  • Medicine

Abstract

Mycosis fungoides (MF) is the most common variant of primary cutaneous T-cell lymphoma (CTCL). It is generally associated with an indolent clinical course and characterised by well-defined clinicopathological features. Although rare, CTCLs constitute 65% of all cutaneous lymphoid malignancies, of which 50% are patients with MF. The erythrodermic variants of MF, a malignancy of mature, skin homing and clonal T lymphocytes, usually present in mid to late adulthood. Association with hypereosinophilia is important in prognosis. We report a case of erythrodermic MF with hypereosinophilic syndrome in a 22-year-old female presenting with gradually progressive intractable erythroderma with intensely pruritic multiple papules, plaques, and nodules involving more than 90% of body surface area. Diagnosis was confirmed by histopathological examination and immunophenotyping from multiple skin biopsies.

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