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Influenza A viruses and PI3K : Are there time, place and manner restrictions?

Landes Bioscience
Publication Date
DOI: 10.4161/viru.20932
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Abstract Virulence 405 Virulence 3:4, 405–419; July 1, 2012; © 2012 Landes Bioscience NEWS NEWS & ViEWS The family Herpesviridae is a large, diverse family of double-stranded enveloped DNA viruses. Herpes B virus (BV) and Cercopithecine herpesvirus 2 (CeHV-2) are simian herpesvi- ruses. Like herpes simplex virus 1 (HSV-1), they belong to the a-herpesvirus subfamily. interest in BV infections results from the observation that zoonotic infections often result in death of humans, whereas infection of macaques, the natural host of BV, results in disease similar to that observed on HSV infections of humans. We recently reported in cell-cell fusion assays in which nectin-1, a HSV-1 gD receptor, medi- ated fusion of cells expressing glycoproteins from both BV and CeHV-2. However, HVEM, another HSV-1 gD receptor, did not medi- ate fusion by BV and CeHV-2 glycoproteins. Paired immunoglobulin-like type 2 receptor a (PiLRa), an HSV-1 gB fusion receptor, did not mediate fusion with BV or CeHV-2 glycopro- teins. These results were further confirmed by BV infection. Our results may indicate that dif- ferential receptor usage by BV in humans when compared with macaques may have patho- logical consequences. Understanding human and simian receptor usage for BV and HSV may provide clues to understand the pathogenesis of these viruses, as well as related viruses, in their natural host as well zoonotic infections. This broader understanding may result in the development of novel therapeutics to control deadly BV infections as well as herpesvirus infections in general. Herpes B virus (BV, officially named as Macacine herpesvirus 1, formerly Herpesvirus simiae, monkey B virus, or Cercopithecine her- pesvirus 1) and Cercopithecine herpesvirus 2 (CeHV-2, formerly simian agent 8) are primate herpesviruses belonging to the a-herpesvirus subfamily and are closely related to herpes simplex virus 1 (HSV-1) and HSV-2. HSV causes recurrent mucocutaneous lesions on th

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