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Stereocontrolled total synthesis of the chiral building block (3S,4R)-3- [(R)-1-hydroxyethyl]-4-acetyloxy-azetidin-2-one: a useful synthon for the synthesis of (+)-thienamycin, carbapenems and penems.

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
26
Issue
7
Identifiers
DOI: 10.1016/s0040-4039(00)61969-x

Abstract

Abstract A total stereocontrolled synthesis of ( 1 ), an intermediate in the synthesis of (+)-thienamycin, carbapenems and penems, based on a strategy that uses the S(-)hydroxy ethylbutyrate as chiral building block, is reported.

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