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Osteoarthritis year in review 2013: biology

Authors
Journal
Osteoarthritis and Cartilage
1063-4584
Publisher
Elsevier
Volume
21
Issue
10
Identifiers
DOI: 10.1016/j.joca.2013.05.020
Keywords
  • Inflammation
  • Signaling
  • Growth Factors
  • Bone
  • Cartilage
  • Meniscus
  • Synovium
Disciplines
  • Biology
  • Medicine

Abstract

Summary The purpose of this review was to present highlights from the published literature on the topic of the biology of osteoarthritis (OA). A PubMed search was conducted in order to locate original research manuscripts published since the last OARSI meeting in 2012. From review of the published literature, common themes emerged as active areas of research over the past year including studies in the areas of epigenetics, Wnt signaling, the role of inflammatory pathways in OA, lubricin, fibroblast growth factor signaling, and studies on OA biology in bone. Key findings in these areas were summarized and implications for future therapies were discussed.

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