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Aphidicolin does not inhibit the repair synthesis of mitotic chromosomes

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
99
Issue
4
Identifiers
DOI: 10.1016/0006-291x(81)90759-2
Disciplines
  • Biology

Abstract

Abstract In order to determine the possible role of α-polymerase in repair synthesis, we measured the unscheduled DNA synthesis stimulated by UV-irradiation in mitotic HeLa cells in the presence of Aphidicolin, a specific inhibitor of this enzyme. The results do not show any inhibition of the unscheduled DNA synthesis,indicating that the function of α-polymerase is not essential for repair synthesis of mitotic cells.

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