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Microencapsulation of Diclofenac Sodium by Nonsolvent Addition Technique

Faculty of Pharmacy, University of Benin
Publication Date
  • Phase Separation
  • Diclofenac Sodium
  • Ethylcellulose
  • Non-Solvent Addition
  • Characterisation.
  • Chemistry
  • Physics


Purpose: To prepare, using non-solvent addition technique, diclofenac sodium-ethylcellulose microparticles with modified drug release properties.Methods: Microparticles were prepared by non-solvent addition phase separation method and characterized by micromeritics, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), x-ray diffraction (XRD), dissolution test and thermal analysis.Results: The microparticles were whitish, irregular, aggregated, and in the size range of 390 - 442 μm size. Drug embedment efficiency was 89 - 91 %. Characterisation studies indicate that there was no strong chemical interaction between the drug and the polymer in the microparticles. Polymer concentration and sustained release behavior were directly proportional.Conclusion: Non-solvent addition phase separation is a suitable method for preparing diclofenac sodium-ethylcellulose multi-unit controlled release drug delivery system.Keywords: Phase separation, Diclofenac sodium, Ethylcellulose, Non-solvent addition, Characterisation.

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