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Role of inflammatory mediators and adhesion molecules in the pathogenesis of aseptic loosening in total hip arthroplasties

Authors
Journal
The Journal of Arthroplasty
0883-5403
Publisher
Elsevier
Publication Date
Volume
10
Issue
6
Identifiers
DOI: 10.1016/s0883-5403(05)80080-4
Keywords
  • Aseptic Loosening
  • Synovial Fluid
  • Prostaglandins
  • Cytokines
  • Adhesion Molecules

Abstract

Abstract Concentrations of prostaglandin E 2, interleukin-6, and interleukin-8 were determined in the hip joint synovial fluid of 20 patients undergoing primary (n = 12) and revision (n = 8) total hip arthroplasties. Levels of soluble adhesion molecules were also investigated in these patients. There was a significant and marked increase in levels of prostaglandin E 2 ( P < .001), interleukin-6 ( P < .011), interleukin-8 ( P < .0002), soluble intercellular adhesion molecule 1 ( P < .07), soluble vascular adhesion molecule 1 ( P < .0006), and soluble endothelial leukocyte adhesion molecule 1 ( P < .0003) in joint fluid of patients undergoing revision. On the basis of these observations, it is suggested that synovial fluid and its inflammatory contents could play a significant role in the pathogenesis of aseptic loosening in total hip arthroplasties.

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