Affordable Access

Publisher Website

Oestrogen receptor transcripts associated with cervical human papillomavirus infection

Authors
Journal
Sexually Transmitted Infections
1368-4973
Publisher
BMJ
Publication Date
Volume
78
Issue
3
Identifiers
DOI: 10.1136/sti.78.3.210
Keywords
  • Original Article
Disciplines
  • Design

Abstract

Objective: Studies have been inconsistent in establishing sex steroids as a risk factor for human papillomavirus (HPV) infections. This study was designed to determine whether cervical oestrogen receptors (as measured by oestrogen receptor transcripts) at the cervix would be associated with cervical HPV infections. Methods: In 175 women, ages 14–44, we tested for the presence of HPV DNA and oestrogen receptors transcripts at the cervix during routine pelvic examinations. All subjects completed a self administered questionnaire regarding sexual and menstrual histories. Results: 40% of the women (n=70) tested positive for HPV at the cervix. Of those women testing positive for HPV, 99% had detectable levels of Oestrogen receptors transcripts (n=69/70). HPV cervical infections were independently associated with presence of Oestrogen receptors transcripts (OR = 39.8, CI=4.4, 361.1) and greater numbers of sexual partners (OR=1.1, CI=1.01, 1.18). Conclusion: Women who expressed higher levels of oestrogen receptors transcripts were significantly more likely to have cervical HPV infection. These results demonstrate that Oestrogen receptors may play an important part in cervical HPV infections.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Oestrogen receptor transcripts associated with cer...

on Sexually transmitted infection... June 2002

Risk factors associated with cervical human papill...

on American Journal of Epidemiolo... Nov 01, 1993

Toll-like receptor 9 (TLR9) gene polymorphisms ass...

on The Journal of international m... August 2013

Human papillomavirus cervical infection and associ...

on Infectious Diseases in Obstetr... Jan 01, 1999
More articles like this..