Affordable Access

Publisher Website

The role of repair in the survival of mammalian cells from heavy ion irradiation: Approximation to the ideal case of target theory

Authors
Journal
Advances in Space Research
0273-1177
Publisher
Elsevier
Publication Date
Volume
9
Issue
10
Identifiers
DOI: 10.1016/0273-1177(89)90427-4
Disciplines
  • Biology

Abstract

Abstract Theories of cellular radiation sensitivity that preclude a significant role for cellular repair processes in the final biological expression of cellular damage induced by ionizing radiation are unsound. Experiments are discussed here in which the cell-cycle dependency of the repair deficiency of the S/S variant of the L5178Y murine leukemic lymphoblast was examined by treatment with the heavy ions, 20Ne, 28Si, 40Ar, 56Fe and 93Nb. Evidence from those studies, which will be described in detail elsewhere, provide support for the notion that as the linear energy transfer (LET ∞) of the incident radiation increases the ability of the S/S cell to repair radiation damage decreases until effectively it is eliminated around 500 keV/μm. In the region of the latter LET ∞ value, the behavior of the S/S cell approximates the ideal case of target theory where post-irradiation metabolism (repair) does not influence cell survival. The expression of this phenomenon among different cell types and tissues will depend upon the actual repair systems involved and other considerations.

There are no comments yet on this publication. Be the first to share your thoughts.