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Genetics of Childhood-onset Schizophrenia

Authors
Journal
Child and Adolescent Psychiatric Clinics of North America
1056-4993
Publisher
Elsevier
Volume
22
Issue
4
Identifiers
DOI: 10.1016/j.chc.2013.06.004
Keywords
  • Childhood-Onset Schizophrenia
  • Genetics
  • Common Alleles
  • Gwas
  • Copy Number Variants
  • Rare Alleles
  • Autism
Disciplines
  • Biology
  • Medicine
  • Pharmacology

Abstract

Schizophrenia is a heritable disorder. The genetic architecture of schizophrenia is complex and heterogeneous. This article discusses genetic studies of childhood-onset schizophrenia (COS) and compares findings in familial aggregation, common allele, and rare allele studies of COS with those for adult-onset schizophrenia (AOS). COS seems to be a rare variant of AOS with greater familial aggregation of schizophrenia spectrum disorders and higher occurrence of rare allelic variants. The usefulness of genetic screening for diagnosis and individualized treatment is limited; however, identifying common pathways through which multiple genes adversely affect neural systems offers great promise toward developing novel pharmacologic interventions.

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