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18F-Flourodeoxy glucose PET-computed tomography in testicular carcinoma: diagnostic and prognostic value.

Authors
  • Soydal, Cigdem1
  • Araz, Mine1
  • Urun, Yuksel2
  • Gulpinar, Basak3
  • Nak, Demet1
  • Ozkan, Elgin1
  • Kucuk, Nuriye Ozlem1
  • 1 Departments of Nuclear Medicine.
  • 2 Medical Oncology.
  • 3 Radiology, Ankara University Medical Faculty, Ankara, Turkey. , (Turkey)
Type
Published Article
Journal
Nuclear medicine communications
Publication Date
Dec 01, 2019
Volume
40
Issue
12
Pages
1268–1274
Identifiers
DOI: 10.1097/MNM.0000000000001093
PMID: 31568190
Source
Medline
Language
English
License
Unknown

Abstract

This study aims to assess the diagnostic role of F-FDG PET/computed tomography in primary staging and restaging of testicular cancer in comparison with contrast-enhanced diagnostic thoracic-abdominopelvic computed tomography. Thirty-two consecutive male patients with testicular carcinoma (median age: 29, min-max: 17-65) who were referred to the nuclear medicine department for F-FDG PET/computed tomography were retrospectively included in the study. Patients were evaluated based on the F-FDG PET/computed tomography indications and germ cell tumor subtypes. On patient-based analysis, overall sensitivity, specificity, PPV, NPV and accuracy of 18F-FDG PET/computed tomography were 71%, 100%, 100%, 30% and 75%. On lesion-based analysis, for evaluation of lymph node metastasis they were 76%, 100%, 100%, 57% and 81%, and for detection of distant metastasis 85%, 100%, 100%, 90% and 93%, respectively. Median SUVmax for seminomas were calculated as 14.2 and for nonseminomas 7.8 (P = 0.62) Mean time to progression and overall survival were calculated as 76.6 ± 10.7 and 111 ± 7.5 months, respectively. Mean overall survival and time to progression for PET-positive and negative groups was not found significant (P = 0.69 and P = 0.81). The only significant factor in predict overall survival was the presence of distant organ metastases in PET/computed tomography (124.6 ± 5.2 vs. 78.7 ± 14.0 months, P = 0.02). In this single-center experience with a limited number of patients, F-FDG PET/computed tomography appears to have a value of staging and restaging for both seminomatous and non-seminomatous GCTs.

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