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18F-fluorobenzyl triphenyl phosphonium: a noninvasive sensor of brown adipose tissue thermogenesis.

Authors
  • Madar, Igal
  • Isoda, Takuro
  • Finley, Paige
  • Angle, James
  • Wahl, Richard
Type
Published Article
Publication Date
May 01, 2011
Volume
52
Issue
5
Pages
808–814
Identifiers
DOI: 10.2967/jnumed.110.084657
PMID: 21498536
Source
Medline
License
Unknown

Abstract

The intense uptake of (18)F-FBnTP into BAT at room temperature and the response to cold stimulation suggest the unique potential advantage of (18)F-FBnTP not only in detecting unstimulated BAT at high contrast but also in quantifying the mitochondrial thermogenic activity. (18)F-FBnTP PET may serve as a useful technique to assess BAT volume and function.

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