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Differentiating effect ofl-tyrosine on the human melanoma cell line IIB-MEL-J

Authors
Journal
Experimental Cell Research
0014-4827
Publisher
Elsevier
Publication Date
Volume
188
Issue
1
Identifiers
DOI: 10.1016/0014-4827(90)90278-i

Abstract

Abstract IIB-MEL-J is a highly heterogeneous newly established human melanoma cell line. The addition of 3 m M, l-tyrosine to the culture medium produced (1) a great decrease in the cell growth rate, (2) a loss of the anchorage-independent growth capacity, and (3) a change in the morphology of the cells to a fibroblastoid aspect. Coincident with these changes, an increase in subpopulations I and II and a decrease in subpopulations III and IV took place. In view of this evidence we consider that the cells have differentiated. The melanin production was not increased by the l-tyrosine treatment, suggesting that differentiation and melanin expression are not strictly correlated.

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