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Salicylate intoxication in children—experience with peritoneal dialysis and alkalinization of the urine

Authors
Journal
The Journal of Pediatrics
0022-3476
Publisher
Elsevier
Publication Date
Volume
64
Issue
6
Identifiers
DOI: 10.1016/s0022-3476(64)80638-7

Abstract

Thirteen children with salicylate intoxication were studied. Seven patients were treated with intravenous fluids and alkali alone and six were treated with a combination of intravenous fluid and alkali and with intermittent peritoneal dialysis by means of 5 per cent albumin in an isoosmotic buffer. With full cognizance of its potential dangers, liberal amounts of sodium bicarbonate were used and no complications were encountered. As has been shown by others, sodium bicarbonate promoted renal excretion of salicylate. However, the combination approach was significantly more effective in removing salicylate from the body. The additional use of peritoneal dialysis is recommended in the treatment of those patients in whom more rapid removal of salicylate is desirable.

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