Affordable Access

Publisher Website

Antinociceptive activity ofQuillaja saponariaMol. saponin extract, quillaic acid and derivatives in mice

Authors
Journal
Journal of Ethnopharmacology
0378-8741
Publisher
Elsevier
Publication Date
Volume
133
Issue
1
Identifiers
DOI: 10.1016/j.jep.2010.09.016
Keywords
  • Analgesic Activity
  • Tail-Flick Assay
  • Hot-Plate Assay
  • Quillaja Saponaria
  • Quillaic Acid
  • Quillaic Acid Derivatives
Disciplines
  • Biology
  • Medicine
  • Pharmacology

Abstract

Abstract Ethnopharmacological relevance Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine. Aim of the study The topical and systemic analgesic effects of a commercial partially purified saponin extract, 3β,16α-dihydroxy-23-oxoolean-12-en-28-oic acid (quillaic acid), methyl 3β,16α-dihydroxy-23-oxoolean-12-en-28-oate and methyl 4-nor-3,16-dioxoolean-12-en-28-oate. Materials and methods The samples were assessed in mice using the topical tail-flick and i.p. hot-plate tests, respectively. Results All the samples showed activity in both analgesic tests in a dose-dependent manner. The most active against tail flick test was commercial partially purified saponin extract (EC50 27.9 mg%, w/v) and more than the ibuprofen sodium. On hot-plate test, methyl 4-nor-3, 16-dioxoolean-12-en-28-oate was the most active (ED50 12.2 mg/kg) and more than the ibuprofen sodium. Conclusions The results of the present study demonstrated that Quillaja saponaria saponins, quillaic acid, its methyl ester, and one of the oxidized derivatives of the latter, elicit dose-dependent antinociceptive effects in two murine thermal models.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Antinociceptive activity of Quillaja saponaria Mol...

on Journal of Ethnopharmacology Jan 07, 2011

Antinociceptive properties of caffeic acid derivat...

on European Journal of Medicinal... Jan 01, 2009

Antinociceptive activity of Channa striatus (harua...

on Journal of Ethnopharmacology July 1997

Topical anti-inflammatory activity of quillaic aci...

on Journal of Pharmacy and Pharma... Jan 18, 2011
More articles like this..