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TET2, a tumor suppressor in hematological disorders

Authors
Journal
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
0304-419X
Publisher
Elsevier
Volume
1825
Issue
2
Identifiers
DOI: 10.1016/j.bbcan.2011.12.002
Keywords
  • Hematology
  • Oncology
  • Tumor Suppressor
  • Mouse Models
  • Epigenetics
Disciplines
  • Biology
  • Medicine

Abstract

Abstract The TET family of proteins has been described a few years ago. Only recently, their roles in DNA modification, through the oxidation of methyl-cytosine, and in normal and malignant development, through the description of TET2 as a tumor suppressor have been documented. The conjunction of these findings has prompted large efforts to understand the biology of these novel entities. Here, we summarize the recent results implicating TET2 in hematological malignancies suggesting that further studies are required to fully understand the role of DNA methylation alterations during transformation.

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