Affordable Access

Publisher Website

Gymnasterol, a new antitumor steroid against IGF-dependent cells fromGymnascella dankaliensis

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
44
Issue
6
Identifiers
DOI: 10.1016/s0040-4039(02)02819-8
Keywords
  • Gymnasterol
  • Insulin-Like Growth Factor
  • Steroid
  • Antitumor Substance
Disciplines
  • Biology

Abstract

Abstract A new antitumor substance, gymnasterol ( 1 ), was isolated from the culture broth of Gymnascella dankaliensis. The structure of 1 was determined to be a novel ergostane steroid on the basis of NMR studies. Gymnasterol selectively inhibited IGF-1-dependent growth of MCF-7 human breast cancer cells.

There are no comments yet on this publication. Be the first to share your thoughts.