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Identifying innate immune pathways of the chicken may lead to new antiviral therapies

Authors
Journal
Veterinary Immunology and Immunopathology
0165-2427
Publisher
Elsevier
Publication Date
Volume
148
Identifiers
DOI: 10.1016/j.vetimm.2011.05.031
Keywords
  • Dsrna
  • Interferon
  • Toll-Like Receptors
  • Rig-I Like Helicases
  • Antivirals
Disciplines
  • Medicine

Abstract

Abstract Zoonotic viruses, such as highly pathogenic avian influenza (HPAI), present a significant threat to both the poultry industry and public health. The present method of controlling avian influenza (AI) relies on good farming practice with limited use of vaccination in some countries. However, new ways to control disease outbreaks might be possible with additional knowledge of the natural host response to virus. Moreover, manipulation of the innate immune system in mammals improves the outcomes following viral infection. A similar approach might be applied to the chicken, nevertheless, a greater knowledge of the chicken innate immune system is required. This review outlines important mammalian antiviral mechanisms that have been modulated to strengthen viral immunity and highlights the potential application of these strategies in the chicken, especially in regards, to AI.

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