Affordable Access

Publisher Website

Acceleration of noradrenaline turnover in the mouse heart by cold exposure

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
4
Issue
23
Identifiers
DOI: 10.1016/0024-3205(65)90258-4

Abstract

Abstract The rate of disappearance of tritiated noradrenaline (NA) from the heart has been used to estimate the turnover of NA in this tissue (1). Although these two parameters were not regarded as identical, it was claimed that any change in the rate of NA turnover would be reflected in the slope of the tritiated NA disappearance curve. The conclusion reached by these authors was that the NA turnover rate in the mouse heart was constant, independent of nerve activity and corresponded to a NA synthesis rate of about 0.12 μg/g/hour. In the present experiments the question whether the NA synthesis rate in the mouse heart can be accelerated by increased nerve activity was studied by comparing the slopes of the tritiated NA disappearance curve in hearts of mice kept in the cold with that in hearts from control mice kept at room temperature.

There are no comments yet on this publication. Be the first to share your thoughts.