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Biological stimulus and drug effect

Authors
Journal
Journal of Theoretical Biology
0022-5193
Publisher
Elsevier
Publication Date
Volume
74
Issue
3
Identifiers
DOI: 10.1016/0022-5193(78)90225-4
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract According to theoretical pharmacology the drug effect is a function of the biological stimulus generated by the association of a drug with its receptor; but the theory provides no method to measure the stimulus or to determine the nature of the functional relationship between stimulus and effect. The present paper demonstrates that the stimulus can be measured provided the equilibrium constant of the drug-receptor association is known; comparison of the stimulus, generated by a given drug concentration, with the effect of the same drug concentration then yields empirical information on the stimulus-effect relationship.

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