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Reduced Mid1 Expression and Delayed Neuromotor Development in daDREAM Transgenic Mice

Authors
Journal
Frontiers in Molecular Neuroscience
1662-5099
Publisher
Frontiers Media SA
Publication Date
Volume
5
Identifiers
DOI: 10.3389/fnmol.2012.00058
Keywords
  • Neuroscience
  • Original Research
Disciplines
  • Biology

Abstract

Downstream regulatory element antagonist modulator (DREAM) is a Ca2+-binding protein that binds DNA and represses transcription in a Ca2+-dependent manner. Previous work has shown a role for DREAM in cerebellar function regulating the expression of the sodium/calcium exchanger 3 (NCX3) in cerebellar granular neurons to control Ca2+ homeostasis and survival of these neurons. To achieve a global view of the genes regulated by DREAM in the cerebellum, we performed a genome-wide analysis in transgenic cerebellum expressing a Ca2+-insensitive/CREB-independent dominant active mutant DREAM (daDREAM). Here we show that DREAM regulates the expression of the midline 1 (Mid1) gene early after birth. As a consequence, daDREAM mice exhibit a significant shortening of the rostro-caudal axis of the cerebellum and a delay in neuromotor development early after birth. Our results indicate a role for DREAM in cerebellar function.

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