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Herpesviruses and intermediate filaments: close encounters with the third type.

Authors
  • 1
Type
Published Article
Journal
Viruses
1999-4915
Publisher
MDPI AG
Publication Date
Volume
3
Issue
7
Pages
1015–1040
Identifiers
DOI: 10.3390/v3071015
PMID: 21994768
Source
Medline
Keywords
  • Epstein-Barr Virus
  • Kaposi’S Sarcoma Associated Herpesvirus
  • Cytomegalovirus
  • Cytoskeleton
  • Herpes Simplex Virus
  • Herpesvirus
  • Infection
  • Intermediate Filament
  • Varicella Zoster Virus

Abstract

Intermediate filaments (IF) are essential to maintain cellular and nuclear integrity and shape, to manage organelle distribution and motility, to control the trafficking and pH of intracellular vesicles, to prevent stress-induced cell death, and to support the correct distribution of specific proteins. Because of this, IF are likely to be targeted by a variety of pathogens, and may act in favor or against infection progress. As many IF functions remain to be identified, however, little is currently known about these interactions. Herpesviruses can infect a wide variety of cell types, and are thus bound to encounter the different types of IF expressed in each tissue. The analysis of these interrelationships can yield precious insights into how IF proteins work, and into how viruses have evolved to exploit these functions. These interactions, either known or potential, will be the focus of this review.

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