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Novel P4 truncated tripeptidyl α-ketoamides as HCV protease inhibitors

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
14
Issue
1
Identifiers
DOI: 10.1016/j.bmcl.2003.09.076
Disciplines
  • Biology
  • Communication

Abstract

Abstract We describe herein the synthesis and evaluation of two series of P-4 truncated tripeptidyl α-ketoamides as HCV serine protease inhibitors. The most promising compound disclosed in this communication 7b demonstrated enzyme binding affinity ( K i) at 0.27 uM.

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