Affordable Access

Publisher Website

Osteoblast response to dimethacrylate composites varying in composition, conversion and roughness using a combinatorial approach

Authors
Journal
Biomaterials
0142-9612
Publisher
Elsevier
Publication Date
Volume
30
Issue
27
Identifiers
DOI: 10.1016/j.biomaterials.2009.05.019
Keywords
  • Composite
  • Contact Angle
  • Cytotoxicity
  • Osteoblast
  • Photopolymerization
  • Surface Topography
Disciplines
  • Mathematics

Abstract

Abstract Dimethacrylate polymers and composites are seeing increased usage in orthopedics. As these applications require the material to integrate with the surrounding tissues, direct contact cytotoxicity assays should be used to assess the biocompatibility. This study utilized a combinatorial testing platform to evaluate the cell response to dimethacrylate composites with a variety of properties on a single sample. MC3T3-E1 pre-osteoblasts were cultured directly on composites with varying filler content, filler type, degree of conversion (DC), and surface topography. Cell viability, density, and area depended on an interplay of the material properties, with low DC causing a reduction in cell area but having minimal effect on cell viability, high filler content causing an increase in cell density, and filler content/type altering the surface roughness as a function of DC. The combinatorial testing platform successfully quantified the effects of numerous material properties on several aspects of the osteoblast response.

There are no comments yet on this publication. Be the first to share your thoughts.