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Allosteric properties of adipose tissue pyruvate kinase

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
43
Issue
1
Identifiers
DOI: 10.1016/s0006-291x(71)80096-7
Disciplines
  • Biology

Abstract

Summary The pyruvate kinase of rat adipose tissue is strongly inhibited by physiological concentrations of alanine. This inhibition is counteracted by FDP + in the μmolar range of concentrations. These effects can be observed independently of the homogenization medium employed and in partially purified preparations of the enzyme. Aging of the preparations tends to produce the loss of the inhibitory and activatory effects, pointing to their allosteric nature.

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