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Sex differences in human epilepsy

Authors
Journal
Experimental Neurology
0014-4886
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.expneurol.2014.04.009
Keywords
  • Brain
  • Epilepsy
  • Mtle
  • Sex Difference
  • Mri
Disciplines
  • Biology
  • Medicine

Abstract

Abstract In the majority of neuropsychiatric conditions, marked gender-based differences have been found in the epidemiology, clinical manifestations, and therapy of disease. Emerging data suggest that gender differences exist also in the epidemiology, and pathophysiology of epilepsy. The present review summarizes the current information regarding gender and epilepsy. These differences are regarded from the perspective of innate sex differences in cerebral morphology, structural and functional connections, and assuming that these differences may render men and women differently vulnerable to epileptogenicity.

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