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Recurrent Thromboembolism, Disseminated Intravascular Coagulation, and Coumarin-induced Skin Necrosis Associated with Protein C Deficiency

Authors
Journal
Pathology - Research and Practice
0344-0338
Publisher
Elsevier
Volume
183
Issue
3
Identifiers
DOI: 10.1016/s0344-0338(88)80127-4
Keywords
  • Coumarin Necrosis
  • Intravascular Coagulation
  • Protein C Deficiency
  • Thromboembolism
  • Skin Necrosis
Disciplines
  • Biology
  • Medicine

Abstract

Summary Defiency of protein C has been reported to be associated with recurrent thrombosis and pulmonary embolism, disseminated intravascular coagulation, and coumarin-induced skin necrosis and peripheral gangrene. That all of these serious and eventually lethal complications of protein C deficiency, including embolic myocardial infarction, may occur in the same person is the subject of this case report and description of pathological findings.

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