Publisher Summary This chapter focuses on a study that was conducted to test for bond strength on a representative matrix of commonly used plastics and the adhesives best suited to them. The block-shear (ASTM D 4501) test was chosen as the test method because it places the load on a thicker section of the test specimen that can withstand higher loads before experiencing substrate failure. For many of the plastics evaluated, the effect of polymer composition on bond strength was evaluated by compounding plastic formulations with the most commonly used additives and fillers for that plastic; common grades were used for the remaining resins. The effect of each additive and filler was determined by comparing the bond strength achieved with the specially compounded formulations to that of the neat plastic. In addition, the effect of surface roughening and chemical treatment of the plastic surface on bond strength was also examined. A table depicting shear strengths of fluoropolymer to fluoropolymer adhesive bonds, which was made by using adhesives and are available from Loctite Corporation are also presented in the chapter.