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Preferential Associations of Alleles of Three Distinct Genes Argue for the Existence of Two Prototype Variants of Human Herpesvirus 7

Authors
Publisher
American Society for Microbiology
Publication Date
Source
PMC
Keywords
  • Recombination And Evolution
Disciplines
  • Biology

Abstract

We had previously described six distinct alleles of the glycoprotein B (gB) gene of human herpesvirus 7 (HHV-7). The genetic changes corresponding to these alleles did not affect gB gene transcription or translation in in vitro assays. The study of distinct HHV-7-positive human samples showed preferential associations of some gB alleles with some alleles of two other genes, distantly located on the HHV-7 genome, coding for the phosphoprotein p100 (p100) and the major capsid protein (MCP). Two allele combinations, corresponding to 44 and 31% of the samples studied, respectively, were interpreted as the genetic signatures of two major prototype HHV-7 variants.

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