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Molecular mechanisms of activated T cell deathin vivo

Authors
Journal
Current Opinion in Immunology
0952-7915
Publisher
Elsevier
Publication Date
Volume
14
Issue
3
Identifiers
DOI: 10.1016/s0952-7915(02)00335-7
Keywords
  • Lymphocyte Activation And Effector Functions
Disciplines
  • Biology

Abstract

Abstract The culmination of the immune response involves the death of the majority of the activated antigen-specific T lymphocytes. The death of these cells is important to prevent autoimmunity, to decrease the metabolic cost to the organism and to ensure T cell homeostasis. This review will focus on the mechanisms that, in animals, control the death of these activated cells. At least two separate types of cell death can occur (activation-induced cell death and activated T cell autonomous death) via death receptors such as Fas or the Bcl-2 related protein Bim, respectively. Finally, adjuvants that enable T cell survival may operate via NF-κB and Bcl-3 rather than cytokines.

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