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The expression of recombinant DNA products in mammalian cells

Authors
Journal
Trends in Biotechnology
0167-7799
Publisher
Elsevier
Publication Date
Volume
3
Issue
12
Identifiers
DOI: 10.1016/0167-7799(85)90035-6
Disciplines
  • Biology
  • Design

Abstract

Abstract Recombinant DNA technology provides the potential to produce in large quantity previously scarce or even completely novel proteins by expression of cloned or designed genes in an appropriate host cell type. It has recently become clear that bacterial expression systems are often inappropriate for complex eukaryotic proteins but the high levels of expression of genes introduced into mammalian cells mean that bulk fermentation of animal cells provides an important alternative for the production of valuable proteins.

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