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Palladium-catalyzed asymmetric allylations of aldehydes via (S)-proline allyl ester enamines

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
30
Issue
12
Identifiers
DOI: 10.1016/s0040-4039(00)99514-5

Abstract

Abstract Treatment of chiral enamine 3 , derived from (S)-proline allyl ester ( 1 ) and 2-phenylpropionaldehyde ( 2 ), with tetrakis(triphenylphosphine)-palladium provided (R)-(-)-2-methyl-2-phenyl-4-pentenylaldehyde ( 5 ) with high enantiomeric excess. The mechanism for this asymmetric induction is discussed.

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