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The inhibitory effect of vitamin E on K-rasmutation at an early stage of lung carcinogenesis in mice

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
323
Issue
1
Identifiers
DOI: 10.1016/s0014-2999(97)00094-0
Keywords
  • Lung Cancer
  • K-Ras
  • Proliferating Cell Nuclear Antigen
  • Vitamin E
  • Chemoprevention

Abstract

Abstract In this study, we investigated the effect of vitamin E on the activation of the K- ras oncogene with a 61st codon A→T mutation at an early stage of urethane-induced lung carcinogenesis in mice. Thirty days after urethane injection, the K- ras mutation was detected in 64% of lung samples tested by mutant-allele-specific amplification. The consumption of a supplemented diet with about 20-times more vitamin E than the control diet, only during the promotion phase or during both the initiation and promotion phases of lung carcinogenesis, reduced the frequency of the mutation to 36 and 18%, respectively. Also, vitamin E suppressed the level of proliferating cell nuclear antigen as a marker of cell proliferation in the lungs of mice treated with urethane. These results support the notion that vitamin E is a useful chemopreventive agent against lung cancer. © 1997 Elsevier Science B.V.

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