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Lipase-mediated asymmetric construction of 2-arylpropionic acids: enantiocontrolled syntheses ofS-naproxen andS-ibuprofen

Authors
Journal
Tetrahedron Asymmetry
0957-4166
Publisher
Elsevier
Publication Date
Volume
8
Issue
13
Identifiers
DOI: 10.1016/s0957-4166(97)00237-1

Abstract

Abstract A general and enantiocontrolled synthetic route to 2-arylpropionic acids, represented by non-steroidal anti-inflammatory drugs S-naproxen 1a and S-ibuprofen 1b, has been developed by employing the lipase-mediated asymmetric acetylation of prochiral 2-aryl-1,3-propanediol 3, which has been derived via a Heck reaction, as the key step.

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