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Ca2+binding of latent transforming growth factor-β1 binding protein

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
320
Issue
2
Identifiers
DOI: 10.1016/0014-5793(93)80079-a
Keywords
  • Transforming Growth Factorβ
  • Binding Protein
  • Egf-Like Repeat
  • Ca2+Binding
Disciplines
  • Biology
  • Communication

Abstract

Abstract Latent transforming growth factor-β1 binding protein (LTBP) is a constituent of the latent high molecular weight complex of TGF-β1 in human platelets. In the present communication, we show that LTBP binds Ca 2+ in its free form as well as in the latent TGF-β1 complex. The binding of Ca 2+ induces a structural change which protects the molecule against proteolysis and changes its elution position when analyzed by anion exchange chromatography. The in vitro activation of TGF-β1 is not influenced by the presence of Ca 2+. The possible significance of Ca 2+ binding of LTBP is discussed.

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