Abstract Situation Awareness (SA) is a fundamental characteristic for a system. For understanding the effective parameters in SA, by describing the Biological Immune System, a model for behavior of antibody are proposed. Furthermore, four levels of Endsley Model of SA (EMSA) will be described and SA process in the proposed model will compared and mapped on EMSA. For simulating the proposed model a notation for agents are introduced and some parameters of two main categories in SA are presented. By running the simulation in different cases, the effect of memory, learning ability and communication in SA of each agent will be illustrated and compared. The results emphasize on importance of learning and communication in SA and robustness of a system. By recognizing the important parameters of SA, designing and implementation of self-aware system would be possible.