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Subtle actions of 2-amino-4-phosphonobutyrate (APB) on the Off pathway in the mudpuppy retina

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
426
Issue
1
Identifiers
DOI: 10.1016/0006-8993(87)90433-1
Keywords
  • Amino Acid
  • Aminobutyric Acid
  • Glutamate
  • Mudpuppy
  • Retina
  • Retinal Ganglion Cell
  • Synaptic Receptor

Abstract

The principal action of 2-amino-4-phosphonobutyrate (APB) applied to the retina is the elimination of the On-bipolar cell light response. In this study, we report that APB also has more subtle effects; it sometimes enhances Off responses of Off bipolar cells and On, Off, and On-Off inner retina neurons. Possible mechanisms for this enhancement are considered.

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