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Proteins of the mammalian mitochondrial ribosome

  • Ribosomes ( Lcsh ) ( Lcsh )
  • Mitochondria ( Lcsh ) ( Lcsh )
  • Proteins ( Lcsh ) ( Lcsh )
  • Biochemistry And Molecular Biology Thesis Ph. D
  • Dissertations
  • Academic -- Biochemistry And Molecular Biology -- Uf
  • Biology
  • Chemistry


Proteins of the mammalian mitochondrial ribosome PROTEINS OF THE MAMMALIAN MITOCHONDRIAL RIBOSOME by DAVID EARL MATTHEWS A DISSERTATION PRESENTED TO THE GRADUATE COUNCIL OF THE UNIVERSITY OF FLORIDA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY UNIVERSITY OF FLORIDA 1976 ACKNOWLEDGEMENTS The author gratefully acknowledges the financial support awarded him in the form of fellowships from the National Science Foundation and the Graduate Council. Thanks are also due to Mark Critoph, Warren Clark, and Mark Moffitt for their technical assistance in these experiments; and to Nancy Denslow, Robert Hessler, and Mary Conde for helpful discussions. The senior research project of Dean Kane contributed much to the studies on the isoelectric points of mitochondrial ribosomal proteins. The encouragement and assistance of Patty Matthews in the preparation of this dissertation were invaluable. The author also wishes to express his gratitude for the helpful- ness of the faculty of the Department of Biochemistry, and of his supervisory committee in particular; their good will, advice, and scientific insights have made the past four years of graduate study a most rewarding experience. Most of all, the profound influence of Dr. Thomas W. O'Brien in shaping this research, as well as the author's scientific training, goals, and attitudes, is humbly and gratefully acknowledged . TABLE OF CONTENTS Acknowledgements ii List of Tables v List of Figures vi Abbreviations Used viii Abstract ix Introduction ; 1 I. Structural properties of non-mitochondrial ribosomes 3 II. Structural properties of mitochondrial ribosomes 7 A. Mitochondrial ribosomes of protists, fungi and plants 7 B. Mitochondrial ribosomes of animals 12 III. Phylogenetic relationships in ribosome structure 17 IV. Summary 21 Materials and Methods 23 I. Materials 23 II. Preparation of ribosomes 25 A. Bovine mitochondrial ribosomes 25 1. Method

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