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A new method for evaluating antitussives in cats using an electrode-cannula

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
34
Issue
1
Identifiers
DOI: 10.1016/0014-2999(75)90225-3
Keywords
  • Dextromethorphan Hydrobromide
  • Antitussive Evaluation
  • Codeine Sulfate
  • Tracheal Electrode-Cannula
  • Carbetapentane Citrate

Abstract

Abstract An emplaced laryngo-tracheal electrode-cannula was employed to induce and to measure cough in cats anesthetized with either sodium pentobarbital or Dial—urethane. Carbetapentane citrate codeine sulfate and dextromethorphan hydrobromide were tested for antitussive action by this method. Relative antitussive potency obtained in order of decreasing effectiveness was dextromethorphan hydrobromide, codeine sulfate and carbetapentane citrate.

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