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ω-Conotoxin GVIA binds to and blocks rat neuromuscular junction

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
176
Issue
2
Identifiers
DOI: 10.1016/0304-3940(94)90078-7
Keywords
  • ω-Conotoxin
  • Rat Neuromuscular Junction
  • N-Type Calcium Channel
  • Nicotinic Receptor
  • Autoradiography
  • α-Bungarotoxin

Abstract

Abstract The effect of ω-conotoxin GVIA, a specific blocker of N-type calcium channels, on the synaptic transmission at the mammalian neuromuscular junction is controversial. We have found that 125I-ω-conotoxin binds to rat tibialis muscle end-plate; that ω-conotoxin blocks the neuromuscular transmission both in vivo, in the sciatic nerve-tibialis anterior muscle, and in vitro in the isolated phrenic nerve-diaphragm preparation; and does not affect muscle nicotinic receptors. We conclude that in rat neuromuscular junctions N-type calcium channels are important for neurotransmitter secretion.

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